Results
| PMID | 17481627 |
| Gene Name | HPSE |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 105 |
| Population details | 105 (91 eutopic endometrial specimens, 14 ectopic endometrial specimens) |
| Sex | Female |
| Associated genes | heparanase-1 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2007 Nov;88(5):1304-10. Epub 2007 May 4. Xu, Xiulong| Ding, Jianchi| Ding, Helen| Shen, Jikun| Gattuso, Paolo| Prinz, Richard A| Rana, Nasir| Dmowski, W Paul Department of General Surgery, Rush University Medical Center, Chicago, IL 60612, USA. xxu@rush.edu OBJECTIVE: To investigate the expression of heparanase-1, an endoglycosidase that degrades heparan sulfate proteoglycans, in eutopic and ectopic endometrial tissues from women with endometriosis. DESIGN: An immunohistochemical study. SETTING: Academic research laboratory and a private infertility clinic affiliated with a university medical center. PATIENT(S): Premenopausal women undergoing laparoscopy for endometriosis. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Expression of heparanase-1 analyzed by immunohistochemical staining in 91 eutopic and 14 ectopic endometrial specimens. RESULT(S): We found that 17% (4/24) of the eutopic endometrial specimens in the early proliferative phase and 32% (9/28) of the samples in the midproliferative phase were heparanase-1 positive. However, >or=80% of eutopic endometrial specimens at late proliferate phase and at luteal phase were heparanase-1 positive. Twelve of 14 ectopic endometriotic specimens stained heparanase-1 positive. Comparison of heparanase-1 expression in paired eutopic and ectopic endometrial tissues revealed that 5 of 6 ectopic specimens in the early proliferative phase were heparanase-1 positive, whereas only 1 eutopic specimen was heparanase-1 positive. In comparison with our recent study of heparanase-1 expression in normal endometrium, we found that there was no significant difference in heparanase-1 expression in the eutopic endometrium from women with or without endometriosis. CONCLUSION(S): Heparanase-1 was differentially expressed in the eutopic endometrium in the different menstrual phases. Heparanase-1 was highly expressed in the ectopic endometriotic lesions regardless of their menstrual phases, suggesting that the local environment is responsible for increased heparanase-1 expression. Mesh Terms: Adult| Choristoma/*enzymology/genetics| Endometriosis/*enzymology/genetics| *Endometrium| Female| Gene Expression Regulation, Enzymologic/*physiology| Glucuronidase/analysis/*biosynthesis/genetics| Humans| Immunohistochemistry| Menstrual Cycle/me |
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